Gene information
Official symbol GDF15
Official full name growth differentiation factor 15
Gene type protein-coding gene
Chromosome19p13.11
Alias symbolPLAB; MIC-1; PDF; MIC1; NAG-1; PTGFB
Gene familyMicroRNA protein coding host genes; Transforming growth factor beta superfamily
Resources
Entrez Gene 9518
HGNC HGNC:30142
Ensembl ENSG00000130513
Vega OTTHUMG00000183360
UCSC uc002niv.2
GO terms: 41 records
GO Description Category LogP Number of genes Detail
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -8.77828157 29 More
GO:0007179 transforming growth factor beta receptor signaling pathway GO Biological Processes -7.95704539 19 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007631 feeding behavior GO Biological Processes -8.63374021 12 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.11509809 13 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030509 BMP signaling pathway GO Biological Processes -5.83413377 15 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040014 regulation of multicellular organism growth GO Biological Processes -9.11971182 17 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060142 regulation of syncytium formation by plasma membrane fusion GO Biological Processes -2.86749174 6 More
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.52187520 15 More
GO:0060395 SMAD protein signal transduction GO Biological Processes -3.01689914 9 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0071772 response to BMP GO Biological Processes -7.7216264 19 More
GO:0071773 cellular response to BMP stimulus GO Biological Processes -7.7216264 19 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:1901739 regulation of myoblast fusion GO Biological Processes -3.76608029 6 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
Drug-Gene interaction
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Related drugs: 5 records
Related studies: 33 records
Molecular factor Omics type Application Objective MI type Reference
cg16008327 hypomethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
NM_004864.4:c.142T>A genomics acute non-ST elevation myocardial infarction[diagnosis] acute non-ST elevation myocardial infarction Jing R et al. Int J Clin Exp Med. 2015
NM_004864.4:c.142T>A genomics collateral circulation[prognosis (good)] acute non-ST elevation myocardial infarction Jing R et al. Int J Clin Exp Med. 2015
NM_004864.4:c.-3148C>G genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Chen XP et al. Rev Assoc Med Bras (1992). 2017
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Kempf T et al. Eur Heart J. 2007
growth/differentiation factor 15 proteomics good predictor death;heart failure[prognosis (bad)] acute myocardial infarction Khan SQ et al. Eur Heart J. 2009
growth/differentiation factor 15 proteomics medium predictor death[prognosis (bad)] acute ST elevation myocardial infarction Eitel I et al. Heart. 2011
growth/differentiation factor 15 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Eitel I et al. Heart. 2011
growth/differentiation factor 15 proteomics medium predictor left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Dominguez-Rodriguez A et al. Am J Cardiol. 2011
growth/differentiation factor 15 proteomics good predictor death[prognosis (bad)] acute myocardial infarction Schaub N et al. Clin Chem. 2012
growth/differentiation factor 15 proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Schaub N et al. Clin Chem. 2012
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute myocardial infarction Fuernau G et al. Eur J Heart Fail. 2014
growth/differentiation factor 15 proteomics cardiovascular adverse events[prognosis (bad)] old myocardial infarction Minamisawa M et al. Int Heart J. 2016
growth/differentiation factor 15 proteomics heart failure[prognosis (bad)] old myocardial infarction Wang FF et al. J Geriatr Cardiol. 2016
growth/differentiation factor 15 proteomics myocardial infarction[diagnosis] myocardial infarction Hagstrom E et al. Clin Chem. 2017
growth/differentiation factor 15 proteomics medium predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Schernthaner C et al. Eur J Clin Invest. 2017
growth/differentiation factor 15 proteomics poor predictor acute non-ST elevation myocardial infarction[diagnosis] acute non-ST elevation myocardial infarction Schernthaner C et al. Eur J Clin Invest. 2017
growth/differentiation factor 15 proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Schernthaner C et al. Eur J Clin Invest. 2017
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute myocardial infarction Skau E et al. Eur J Prev Cardiol. 2017
growth/differentiation factor 15 proteomics contrast-induced nephropathy[prognosis (bad)] acute myocardial infarction Sun L et al. PLoS One. 2018
growth/differentiation factor 15 proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Sun L et al. PLoS One. 2018
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute myocardial infarction Sun L et al. PLoS One. 2018
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute myocardial infarction Liu JX et al. J Geriatr Cardiol. 2018
growth/differentiation factor 15 proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Liu JX et al. J Geriatr Cardiol. 2018
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Bodde MC et al. Cardiol Ther. 2019
growth/differentiation factor 15 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Rueda F et al. Clin Chem Lab Med. 2019
growth/differentiation factor 15 proteomics death;readmission due to cardiovascular disease[prognosis (bad)] acute ST elevation myocardial infarction Rueda F et al. Clin Chem Lab Med. 2019
growth/differentiation factor 15 proteomics good predictor death[prognosis (bad)] acute myocardial infarction Walter J et al. Int J Cardiol. 2019
growth/differentiation factor 15 proteomics sudden cardiac death[prognosis (bad)] acute myocardial infarction Andersson J et al. Resuscitation. 2020
growth/differentiation factor 15 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Sabirzyanova AA et al. Russian. 2020
growth/differentiation factor 15 proteomics coronary artery disease[prognosis (bad)] ST elevation myocardial infarction Velders MA et al. Am Heart J. 2015
growth/differentiation factor 15 proteomics type 1 myocardial infarction[diagnosis] ST elevation myocardial infarction Velders MA et al. Am Heart J. 2015
growth/differentiation factor 15 proteomics contrast-induced acute kidney injury[prognosis (bad)] acute myocardial infarction Sun L et al. PLoS One. 2018
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